According Paul J. Ponganis and Gerald L. Kooyman of the Center for Marine Biotechnology and Biomedicine at Scripps Institution of Oceanography, some cetatceans (whales, orca, dolphins, porpoise) have a number of unique physiological adaptations enabling seep sea dives.
How deep? Sperm whales - which have the largest brain of any animal so far discovered...at 15 lbs! - have been recorded making hour long dives as deep as 6000 feet, over a mile down.
Link via reddit.
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